Clinical Cancer Research
Clinical Cancer Research
4 years ago

Genotyping Natural Killer immune checkpoints to discover biomarkers of response.

Nai-Kong V Cheung, Katharine C Hsu
Immune checkpoints have been a focus of immunotherapy in the recent decade. Killer-cell immunoglobulin-like receptors (KIR) and their cognate human leukocyte antigen (HLA) class I ligands have evolved as checkpoints to ensure self-tolerance of natural iiller (NK) cells. Both KIR and HLA genetic profiles are potential biomarkers of immunotherapy outcome.

Publisher URL: http://doi.org/10.1158/1078-0432.CCR-17-2884

DOI: 10.1158/1078-0432.CCR-17-2884

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