5 years ago

New Generation of Ultrasensitive Label-Free Optical Si Nanowire-Based Biosensors

New Generation of Ultrasensitive Label-Free Optical Si Nanowire-Based Biosensors
Alessia Irrera, Maria Josè Lo Faro, Kyriaki Manoli, Cristiano D’Andrea, Francesco Priolo, Luisa Torsi, Antonio Alessio Leonardi, Barbara Fazio, Paolo Musumeci, Giorgia Franzò, Gerardo Palazzo, Cinzia Di Franco
We demonstrate the realization of the first label-free optical biosensor based on the room temperature luminescence of silicon nanowires (NWs) tested for the selective detection of C-reactive protein in human serum. High aspect ratio Si NW arrays used as sensing interface, are synthesized by a fast, low cost and Si industrially compatible approach. Si NW optical biosensors are fast and offer a broad concentration dynamic range that can be tuned according to different applications. Moreover, the platform is endowed with a high selectivity toward the target analyte and a sensitivity down to the fM limit of detection, opening the route toward noninvasive analysis in biofluids such as saliva.

Publisher URL: http://dx.doi.org/10.1021/acsphotonics.7b00983

DOI: 10.1021/acsphotonics.7b00983

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