Naphthoquinones: a continuing source for discovery of therapeutic antineoplastic agents

4 years ago

Naphthoquinones: a continuing source for discovery of therapeutic antineoplastic agents

Han-Yue Qiu, Cheng-Yi Tang, Hong-Yan Lin, Yong-Hua Yang, Hai-Liang Zhu, Peng-Fei Wang

Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been implicated with human life since ancient time, far earlier than their isolation and identification in modern era. The long use history of naphthoquinones has witnessed their functional shift from the original purposes as dyes and ornaments towards medicinal benefits. Hitherto, numerous studies have been carried out to elucidate the pharmacological profile of both natural and artificial naphthoquinones. A number of entities have been identified with promising therapeutic potential. Apart from the traditional effects of wound healing, anti-inflammatory, hemostatic, antifertility, insecticidal and antimicrobial, etc., the anticancer potential of naphthoquinones either in combination with other treatment approaches or on their own is being more and more realized. The molecular mechanisms of naphthoquinones in cells mainly fall into two categories as inducing oxidant stress by ROS (reactive oxygen species) generation, or directly interacting with traditional therapeutic targets in a non-oxidant mechanism. Based on this knowledge, optimized agents with naphthoquinones scaffold have been acquired and further tested. Hereby, we summarize the explored biological mechanisms of naphthoquinones in cells and review the application perspective of promising naphthoquinones in cancer therapies. This article is protected by copyright. All rights reserved. The explored biological mechanisms of naphthoquinones in cellular and the application perspective of promising naphthoquinones in cancer therapies were reviewed.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/cbdd.13141