Nanomedicine
Nanomedicine
5 years ago

Exosome Function in Aerodigestive Mucosa.

Angela L Nocera, Sarina K Mueller, Benjamin S Bleier
Exosomes are 30-150nm membrane-bound vesicles which are secreted by virtually all cell types. Exosomes have been studied in a wide range of both normal and pathologic human tissues, most notably cancer. The role of exosomes in immune surveillance, non-invasive biomarker sampling, and their potential to act as therapeutic carriers lends particular importance to mucosal barrier derived exosomes. This review focuses specifically on current knowledge regarding exosomes derived from aerodigestive membranes. Specific topics covered include: isolation and characterization techniques, physiological function, protein expression, function as biomarkers of disease, and potential therapeutic uses.

Publisher URL: http://doi.org/10.1016/j.nano.2017.10.008

DOI: 10.1016/j.nano.2017.10.008

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