Journal of Applied Polymer Science
Journal of Applied Polymer Science
4 years ago

Self-assembled micelles prepared from poly(ɛ-caprolactone)–poly(ethylene glycol) and poly(ɛ-caprolactone/glycolide)–poly(ethylene glycol) block copolymers for sustained drug delivery

Self-assembled micelles prepared from poly(ɛ-caprolactone)–poly(ethylene glycol) and poly(ɛ-caprolactone/glycolide)–poly(ethylene glycol) block copolymers for sustained drug delivery
Xue Liu, Xiangke Sun, Chenglong Li, Feng Su, Yuandou Wang, Suming Li, Li Liu
A series of poly(ɛ-caprolactone)–poly(ethylene glycol) (PCL-PEG) and poly(ɛ-caprolactone/glycolide)–poly(ethylene glycol) [P(CL/GA)-PEG] diblock copolymers were prepared by ring-opening polymerization of ɛ-caprolactone or a mixture of ɛ-caprolactone and glycolide using monomethoxy PEG (mPEG) as macroinitiator and Sn(Oct)2 as catalyst. The resulting copolymers were characterized using 1H-NMR, gel permeation chromatography, differential scanning calorimetry, and wide-angle X-ray diffraction. Copolymer micelles were prepared using the nanoprecipitation method. The morphology of the micelles was spherical or worm-like as revealed by transmission electron microscopy, depending on the copolymer composition and the length of the hydrophobic block. Introduction of the glycolide component, even in small amounts (CL/GA = 10), disrupted the chain structure and led to the formation of spherical micelles. Interestingly, the micelle size decreased with the encapsulation of paclitaxel. Micelles prepared from mPEG5000-derived copolymers exhibited better drug loading properties and slower drug release than those from mPEG2000-derived copolymers. Drug release was faster for copolymers with shorter PCL blocks than for those with longer PCL chains. The introduction of glycolide moieties enhanced drug release, but the overall release rate did not exceed 10% in 30 days. In contrast, drug release was enhanced in acidic media. Therefore, these bioresorbable micelles and especially P(CL/GA)-PEG micelles with excellent stability, high drug loading content, and prolonged drug release could be promising for applications as drug carriers. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45732

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/app.45732

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