4 years ago

Asymptomatic Clostridium difficile Carriage Rate Post-Fecal Microbiota Transplant is Low: A Prospective Clinical and Stool Assessment

We aimed to assess the asymptomatic C. difficile carriage rates following FMT. Methods All patients who underwent FMT for recurrent CDI via colonoscopy or sigmoidoscopy between June 2013 and April 2015 and had a minimum of 8-week follow-up post-FMT at two tertiary care referral centers were included in the study. Patients were prospectively followed both clinically and with stool assessments for 8 weeks post FMT. Assessments occurred at 1 week and 4 weeks post-FMT to assess for failure. Failure was defined as presence of diarrheal symptoms and a positive CDI stool test by polymerase chain reaction for toxin gene (PCR) at any time point during the 8-week follow up period. CDI stool testing using PCR was performed at weeks 1 and 4 post-FMT in asymptomatic patients as well. Results 167 patients were included. Twenty-eight patients (16.7% [28/167]) were FMT failures throughout the 8-week period. At week 1, 7 patients had already failed the FMT. Of the remaining 160 patients, 144 were asymptomatic, and among these, 141 were negative for c. difficile toxin gene by PCR. This resulted in an asymptomatic carriage rate of 2.1% (3/144). At week 4, 143 patients had not yet failed FMT. Of these patients 129 patients were asymptomatic and among those, 125 were negative by PCR, resulting in an asymptomatic carriage rate of 3% (3/129). Conclusions Asymptomatic carriage after FMT is rare. This suggests testing for cure after FMT in asymptomatic patients is not necessary.

Publisher URL: www.sciencedirect.com/science

DOI: S1198743X17305955

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