Does CSF1R Blockade Turn into Friendly Fire?
In this issue of Cancer Cell, Kumar et al. describe how CSF1R blockade induces not only an expected deprivation of tumor-associated macrophages, but also an accumulation of tumor-infiltrating polymorphonuclear mononuclear cells caused by Cxcl-1 released from cancer-associated fibroblasts.
Publisher URL: http://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30465-8
DOI: 10.1016/j.ccell.2017.10.012
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