Journal of Biological Chemistry
Journal of Biological Chemistry
4 years ago

Orchestrating phospholipid biosynthesis: Phosphatidic acid conducts and Opi1p performs.

Michael Salsaa, Kendall Case, Miriam L Greenberg
Phosphatidic acid (PA) and the conserved integral ER membrane protein Scs2p regulate localization of the transcriptional repressor Opi1p, which controls expression of phospholipid biosynthesis genes, but the mechanisms conducting Opi1p localization are not fully understood. A new study suggests the existence of a distinct pool of PA in the ER that is required for regulation of Opi1p localization and thus phospholipid metabolism in yeast.

Publisher URL: http://doi.org/10.1074/jbc.H117.809970

DOI: 10.1074/jbc.H117.809970

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