Organic Letters
Organic Letters
5 years ago

Citrifurans A–D, Four Dimeric Aromatic Polyketides with New Carbon Skeletons from the Fungus Aspergillus sp.

Citrifurans A–D, Four Dimeric Aromatic Polyketides with New Carbon Skeletons from the Fungus Aspergillus sp.
Jian-Li Lei, Ya-Rong Wu, Tian-Xiao Li, Ming-Hua Yang, Guo-Ping Yin, Xiao-Bing Wang, Ling-Yi Kong, Miao-Miao Zhou
Citrifurans A–D (1–4), metabolized by an Aspergillus sp., are unusual dimers of azaphilone and furanone derivatives. Michael addition was thought to be the pivotal procedure in their biosynthesis, and different addition sites generated two new different carbon skeletons. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction, chemical conversion, and electronic circular dichroism analyses. Compounds 1–3 showed moderate inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 18.3, 22.6, and 25.3 μM, respectively.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01823

DOI: 10.1021/acs.orglett.7b01823

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