4 years ago

Cationic–anionic palladium complexes: effect of hydrogen bond character on their stability and biological activity

O. S. Erofeeva, A. V. Churakov, I. A. Efimenko, N. A. Ivanova, L. I. Demina


The solution state of palladium cationic–anionic complexes (AmH n ) k [PdCl4] prepared for the first time, where Am is morpholine, methylmorpholine, aminoethylmorpholine, 5-aminovaleric acid, L-1-phenyl-2-methylaminopropanol, and m-xylilenediamine, has been studied by electronic absorption spectroscopy, NMR, and pH measurements. The agreement of obtained results for the state of the complexes in water and NaCl solutions with IR and X-ray diffraction data for these complexes has allowed us to substantiate the principle for designing patent formulation (C5H12NO)2[PdCl4], a new type of palladium complexes, palladium(II) cationic–anionic complexes showing high antitumor and antimetastatic activity. Crystallographic data for six obtained complexes have been presented.

Publisher URL: https://link.springer.com/article/10.1134/S0036023617110043

DOI: 10.1134/S0036023617110043

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