Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging

Ming Xian, Jacob J Day, Shi Xu, Difei Wang, Wei Chen
Near-infrared (NIR) fluorescent dyes with favorable photophysical properties are highly useful for bioimaging, but such dyes are still rare. Here, we describe the development of a unique class of NIR dyes via modifying the rhodol-scaffold with fused tetrahydroquinoxaline rings. These new dyes showed large Stokes shifts (>110 nm). Among them, WR3, WR4, WR5 and WR6 displayed high fluorescence quantum yields and excellent photostability in aqueous solutions. Moreover, their fluorescence properties were tunable by easy modifications on the phenolic hydroxyl group. Based on WR6, two NIR fluorescent turn-on probes, WSP-NIR and SeSP-NIR, were devised for the detection of H2S. The probe SeSP-NIR was applied in visualizing intracellular H2S. The dyes presented herein are expected to be useful fluorophore scaffolds in the development of new NIR probes for bioimaging.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201710688

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