Organic Letters
Organic Letters
5 years ago

Hydroxytrifluoromethylation of Alkenes Using Fluoroform-Derived CuCF3

Hydroxytrifluoromethylation of Alkenes Using Fluoroform-Derived CuCF3
Lisi He, Xinkan Yang, Gavin Chit Tsui
Hydroxytrifluoromethylation of alkenes using the fluoroform (CF3H)-derived [CuCF3] reagent is described. In the presence of additive B2Pin2 and air, this reagent effectively facilitates the addition of hydroxy and trifluoromethyl groups across an alkene double bond, a formal hydroxytrifluoromethylation process. Various β-trifluoromethyl alcohols can be synthesized from simple alkenes where the ultimate CF3 source is the industrial byproduct fluoroform.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01085

DOI: 10.1021/acs.orglett.7b01085

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