4 years ago

RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan [version 3; referees: 2 approved, 1 approved with reservations]

Sangsoon Park, Dongyeop Lee, Yoonji Jung, Heehwa G. Son, Wooseon Hwang, Seon Woo A. An, Yujin Lee, Dae-Eun Jeong, Murat Artan, Seung-Jae V. Lee, Hae-Eun H. Park
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that knocking down each of 24 out of total 29 C. elegans α-arrestins had little effect on lifespan. Thus, individual C. elegans α-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity.

Publisher URL: https://f1000research.com/articles/6-1515/v3

DOI: 10.12688/f1000research.12337.3

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