Chemical Biology and Drug Design
Chemical Biology and Drug Design
5 years ago

Photodynamic Therapy and Nuclear Imaging Activities of Zinc Phthalocyanine Integrated TiO2 Nanoparticles in Breast and Cervical Tumors

Photodynamic Therapy and Nuclear Imaging Activities of Zinc Phthalocyanine Integrated TiO2 Nanoparticles in Breast and Cervical Tumors
Cıgır Biray Avci, Cansu Caliskan Kurt, Hale Melis Soylu, Suleyman Gokhan Colak, Ozge Er, Kasim Ocakoglu, Cumhur Gunduz, Mine Ince, Fatma Yurt
In recent years, phthalocyanines (Pcs) have been widely used as photosensitizer in photodynamic therapy applications. Because of their strong absorptions in the near-infrared region (640-700 nm). The integration of phthalocyanine derivatives to a nanoparticle is expected to be efficient way to improve the activity of the photosensitizer on the targeted tissue. It is known that the integrated molecules not only show better accumulation on tumor tissue but also reduce toxicity in healthy tissues. In this study, the ZnPc molecule was synthesized and integrated to the TiO2 nanoparticle, to investigate the potential of PDT and its cytotoxicity. Additionally, ZnPc and ZnPc-TiO2 molecules were labelled with 131I and it was aimed to put forth the nuclear imaging/therapy potentials of 131I labeled ZnPc/ZnPc-TiO2 by determining in vitro uptakes in mouse mammary carcinoma (EMT6), human cervical adenocarcinoma (HeLa). In result of our study, it was observed that the radiolabeling yields of the synthesized ZnPc and ZnPc-TiO2 with 131I were quite high. In vitro uptake studies shown that 131I-ZnPc-TiO2 could be a potential agent for nuclear imaging/treatment of breast and cervical cancers. According to PDT results ZnPc-TiO2 might have as to be a potential PDT agent in the treatment of ovary tumor. ZnPc and ZnPc-TiO2 might be used as theranostic agents. This article is protected by copyright. All rights reserved. New phthalocyanine and TiO2 integrated phthalocyanine were synthesized and their nuclear imaging and PDT potentials were evaluated in tumor cell lines.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/cbdd.13144

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