5 years ago

Coordination-responsive drug release inside gold nanorod@metal-organic framework core–shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy

Ke Hou, Jiawei Lv, Yantao Li, Dawei Wang, Jun Jin, Zhiyong Tang, Chunying Chen, Yaling Liu


Multifunctional core–shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms inrecent years. In this work, crystalline zeolitic imidazolate framework-8 (ZIF-8), a typical metal-organic framework (MOF), is coated onto single gold nanorod(AuNR) core for successful realization of synergistic photothermal andchemotherapy triggered by near-infrared (NIR) light. Impressively, high doxorubicin hydrochloride (DOX) loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented throughformation and breakage of coordination bonds in the system. Moreover, underNIR laser irradiation at 808 nm, these novel AuNR@MOF core–shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation viaintravenous injection.

Publisher URL: https://link.springer.com/article/10.1007/s12274-017-1874-y

DOI: 10.1007/s12274-017-1874-y

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