4 years ago

Longitudinal Change in Central Corneal Thickness in the Tema Eye Survey

To determine the change and rate of change in central corneal thickness (CCT) and their determinants. Design Longitudinal observational population-based study. Methods 758 normal and 58 glaucomatous subjects underwent complete eye examination, with CCT measurements at two separate visits. Change and rate of change in CCT were determined. Univariate and multivariate linear regression analyses were performed to determine the factors associated with change and rate of change. Results The mean follow-up duration was 8.4 ± 0.7 years. The overall change was -8.9 ± 16.7 μm in OD and -9.8 ± 16.2 μm in OS, both P < .0001. Changes in glaucomatous and normal subjects were -14.1 ± 2.2 μm vs. -8.6 ± 0.6 μm in OD (P = .02) and -14.5 ± 2.2 μm vs. -9.5 ± 0.6 μm in OS (P = .03), respectively. The overall rate of thinning was -1.1 μm/year (OD) and -1.2 μm/year (OS). Rates in glaucomatous and normal were -1.7 ± 0.3 vs. -1.0 ± 0.1 μm/year in OD (P = .02) and -1.7 ± 0.3 vs. -1.1 ± 0.1 μm/year in OS (P = .03), respectively. Change and rate of change were associated with baseline CCT (ß = -0.1 to -0.09 and -0.011, respectively, all P < .001) and glaucoma (ß = -6.8 to -5.6, P ≤ .009 and -0.75 to -0.69, P ≤ .007, respectively). Conclusion CCT decreased significantly over time. The change and rate of change were greater in glaucomatous than normal eyes, and greater than described in cross-sectional studies.

Publisher URL: www.sciencedirect.com/science

DOI: S0002939417304774

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.