American Journal of Transplantation
American Journal of Transplantation
4 years ago

Primary Graft Dysfunction after Heart Transplantation: Incidence, Trends and Associated Risk Factors

Chetan B. Patel, Jacob Schroeder, Adam Kretzer, Alina Nicoara, Mark Stafford-Smith, David Ruffin, Joseph G. Rogers, Adrian F. Hernandez, Raquel R. Bartz, Mihai V. Podgoreanu, Mani A. Daneshmand, Carmelo A. Milano, Annemarie Thompson, Mary Cooter, Madhav Swaminathan
Changes in heart transplant (HT) donor and recipient demographics may influence the incidence of primary graft dysfunction (PGD). We conducted a retrospective study to evaluate PGD incidence, trends, and associated risk factors by analyzing consecutive adult patients who underwent HT between January 2009 and December 2014 at our institution. Patients were categorized as having PGD using the International Society of Heart and Lung Transplantation defined criteria. Variables, including clinical and demographic characteristics of donors and recipients, were selected to assess their independent association with PGD. A time-trend analysis was performed over the study period. Three-hundred seventeen patients met inclusion criteria. Left ventricular PGD, right ventricular PGD or both were observed in 99 (31%) patients. Risk factors independently associated with PGD included ischemic time, recipient African-American race, and recipient amiodarone treatment. Over the study period, there was no change in the PGD incidence, however there was an increase in the recipient pre-transplant use of amiodarone. The rate of 30-day mortality was significantly elevated in those with PGD vs those without PGD (6.06% vs 0.92%, P=0.01). Despite recent advancements, incidence of PGD remains high. Understanding associated risk factors may allow for implementation of targeted therapeutic interventions. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/ajt.14588

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.