Molecular Pharmaceutics
Molecular Pharmaceutics
4 years ago

Biogenic Nanostructured Porous Silicon as a Carrier for Stabilization and Delivery of Natural Therapeutic Species

Biogenic Nanostructured Porous Silicon as a Carrier for Stabilization and Delivery of Natural Therapeutic Species
Jeffery L. Coffer, Armando Loni, Leigh T. Canham, Nguyen T. Le, Jhansi R. Kalluri
Nanostructured mesoporous silicon (pSi) derived from the silicon-accumulator plant Tabasheer (Bambuseae) is demonstrated to serve as a potential carrier matrix for carrying and stabilizing naturally active, but otherwise metastable, therapeutic agents. Particularly, in this study, garlic oil containing phytochemicals (namely, allicin) that are capable of inhibiting Staphylococcus aureus (S. aureus) bacterial growth were incorporated into Tabasheer-derived porous silicon. Thermogravimetric analysis (TGA) indicated that relatively high amounts of the extract (53.1 ± 2.2 wt %) loaded into pSi are possible by simple infiltration. Furthermore, by assessing the antibacterial activity of the samples using a combination technique of agar disk diffusion and turbidity assays against S. aureus, we report that biogenic porous silicon can be utilized to stabilize and enhance the therapeutic effects of garlic oil for up to 4 weeks when the samples were stored under refrigerated conditions (4 °C) and 1 week at room temperature (25 °C). Critically, under ultraviolet (UV) light (365 nm) irradiation for 24 h intervals, plant-derived pSi is shown to have superior performance in protecting garlic extracts over porous silica (pSiO2) derived from the same plant feedstock or extract-only controls. The mechanism for this effect has also been investigated.

Publisher URL: http://dx.doi.org/10.1021/acs.molpharmaceut.7b00638

DOI: 10.1021/acs.molpharmaceut.7b00638

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