4 years ago

Canagliflozin: Cui Bono?

Mikhail Kosiborod, Matthew A Cavender
Cardiovascular disease accounts for the majority of excess deaths seen in patients with Type 2 diabetes (T2D).(1) Thus, in order to improve outcomes in this population, clinicians should focus on therapies that decrease the risk of subsequent cardiovascular events. Over the last two years, randomized controlled clinical trials have identified several agents that decrease cardiovascular events in patients with T2D with or at high risk for cardiovascular disease (CVD) - effects likely unrelated to glucose-lowering, the indication for which they were originally developed.(2-5) One of these therapies (empagliflozin), a sodium glucose co-transporter-2 inhibitor (SGLT-2i), was found to reduce the risks of major adverse cardiovascular events (MACE), CV death, hospitalization for heart failure, and progression of nephropathy in patients with CVD.(2) However, it is unknown whether SGLT-2i can also reduce cardiovascular events in the lower risk population of patients with T2D but without established CVD.

Publisher URL: http://doi.org/10.1161/CIRCULATIONAHA.117.032198

DOI: 10.1161/CIRCULATIONAHA.117.032198

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