Aquaculture
Aquaculture
5 years ago

Unraveling the associations of the tilapia DNA polymerase delta subunit 3 (POLD3) gene with saline tolerance traits

DNA polymerases play important roles in repairing synthesis of DNA damage in cells induced by environmental stress. However, little information about function of DNA polymerase delta for DNA damage that induced by salinity stress was available. In our study, we identified 7 SNPs in a subunit of DNA polymerase delta, POLD3, and found that these SNPs were significantly associated with saline tolerance traits in a full-sib family of Nile tilapia (N=192). The expression of the POLD3 gene was also dramatically regulated at brain, gill and intestine in response to the acute salinity challenges as indicated by qRT-PCR. Our data indicated that the POLD3 gene itself or close-linked genes played important roles in saline tolerance in tilapia and provided a basis for developing molecular marker resources from POLD3 gene for breeding of salt-tolerant tilapia in future.

Publisher URL: www.sciencedirect.com/science

DOI: S0044848617312899

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.