Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
4 years ago

Highly Selective Manganese(I)/Lewis Acid Cocatalyzed Direct C−H Propargylation using Bromoallenes

Frank Glorius, Can Zhu, Luca Jonas Schwarz, Sara Cembellin, Steffen Greßies
A manganese(I)/Lewis acid cocatalyzed direct C−H propargylation with high selectivity has been developed. BPh3 was discovered to not only promote the reactivity, but also enhance the selectivity to afford the propargylation products rather than allene derivatives. Secondary, tertiary or even quaternary carbon centers at the propargylic position could be directly constructed. Both internal and terminal alkynes are easily accessible. The chirality was successfully transferred from an axially chiral allene to the central chirality. The reactivity of the manganese catalyst in this chemistry was found to be unique comparing other transition metal catalysts.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201710835

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.