Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Deep Level Defect-Enhanced Photothermal Performance of Bismuth Sulfide-Gold Heterojunction Nanorods for CT Imaging-Guided Photothermal Therapy of Cancer

Haiyuan Zhang, Yun Chang, Zhaohui Tang, Yan Cheng, Yanlin Feng, Hui Jian
Bismuth sulfide (Bi2S3) nanomaterials are emerging as a promising theranostic platform for CT imaging and photothermal therapy of cancer. Herein, the photothermal property of Bi2S3 nanorods (NRs) was unveiled to intensely correlate to their intrinsic deep level defects (DLDs) that potentially could work as electron-hole nonradiative recombination centers to promote phonon production, ultimately leading to photothermal performance. Bi2S3-Au heterojunction NRs were designed to hold more significant DLD property, exhibiting more potent photothermal performance than Bi2S3 NRs. Under 808 nm laser irradiation, Bi2S3-Au NRs could trigger higher cellular heat shock protein 70 expression and more apoptotic cells than Bi2S3 NRs, and caused severe cell death and tumor growth inhibition, showing great potential for CT imaging-guided photothermal therapy of cancer.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201710399

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