Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry
5 years ago

Specifically targeting mixed-type dimeric G-quadruplexes by berberine dimers

Chun-qiong Zhou, Jian-Wei Yang, Wen-Hua Chen, Zi-Qi Li, Li-Hong Liu, Cheng Dong, Yuan Luo, Xiao-Jie Chen, Ting-Cong Liao, Yuan-Yuan Liang
Three polyether-tethered berberine dimers (1a-c) have been studied on their binding affinity, selectivity and thermal stabilization towards human telomeric dimeric quadruplex DNA (G2T1). Compound 1a with the shortest polyether linker...

Publisher URL: http://feeds.rsc.org/~r/rss/OB/~3/pDRNSoI8-jg/C7OB02326J

DOI: 2017/OB/C7OB02326J

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