5 years ago

Controlling miRNA-like Off-target Effects of an siRNA with Nucleobase Modifications

Hassan Owens, Madeline M. Mumbleau, Alexi A Ball-Jones, Andrew Fisher, Scott Ryan Suter, Rachel Valenzuela, Jose M. Ibarra-Soza, Peter A Beal
SiRNAs can cause unintended gene silencing due to miRNA-like effects because of the similarity in function of an siRNA guide strand and a miRNA. Here we evaluate the effect on...

Publisher URL: http://feeds.rsc.org/~r/rss/OB/~3/yfwGjq4Maxo/C7OB02654D

DOI: 2017/OB/C7OB02654D

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