ChemCatChem
ChemCatChem
4 years ago

Alkylation of Ketones Catalyzed by Bifunctional Iron Complexes: From Mechanistic Understanding to Application

Alkylation of Ketones Catalyzed by Bifunctional Iron Complexes: From Mechanistic Understanding to Application
Jean-François Lohier, Sébastien Coufourier, Charlotte Seck, Mbaye Diagne Mbaye, Thomas R. Ward, Jean-Luc Renaud, Alexis Lator, Albert Poater, Sylvain Gaillard
Cyclopentadienone iron dicarbonyl complexes were applied in the alkylation of ketones with various aliphatic and aromatic ketones and alcohols via the borrowing hydrogen strategy in mild reaction conditions. DFT calculations and experimental works highlight the role of the transition metal Lewis pairs and the base. These iron complexes demonstrated a broad applicability in mild conditions and extended the scope of substrates. Borrow hydrogen for iron complexes: A cyclopentadienone iron dicarbonyl complex is applied in the alkylation of ketones with various aliphatic and aromatic ketones and alcohols through the borrowing hydrogen strategy in mild reaction conditions. DFT calculations and experimental works highlight the role of this transition metal Lewis pair and the base.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cctc.201701241

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