3 years ago

Poly(amino acid)-Based Gel Fibers with pH Responsivity by Coaxial Reactive Electrospinning

Poly(amino acid)-Based Gel Fibers with pH Responsivity by Coaxial Reactive Electrospinning
Angela Jedlovszky-Hajdu, Shaohua Jiang, Seema Agarwal, Kristof Molnar, Miklos Zrinyi
Electrospinning is a well-known technique for the preparation of scaffolds for biomedical applications. In this work, a continuous electrospinning method for gel fiber preparation is presented without a spinning window. As proof of concept, the preparation of poly(aspartic acid)-based hydrogel fibers and their properties are described by using poly(succinimide) as shell polymer and 2,2,4(2,4,4)-trimethyl-1,6-hexanediamine as cross-linker in the core of the nozzle. Cross-linking takes place as the two solutions get in contact at the tip of the nozzle. The impact of solution concentrations and feeding rates on fiber morphology, proof of the presence of cross-links as well as pH sensitivity after the transformation of the poly(succinimide)-based material to poly(aspartic acid) is presented. In this paper, a new synthetic pathway for amino-acid-based gel fibers is presented using a coaxial reactive electrospinning technique, where fiber formation can be achieved in a continuous way. As proof of concept, the preparation of poly(aspartic acid)-based hydrogel fibers and their properties are described.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/marc.201700147

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