5 years ago

Mechanically strong hyaluronic acid hydrogels with an interpenetrating network structure

Mechanically strong hyaluronic acid hydrogels with an interpenetrating network structure
Hyaluronic acid (HA) is a natural glycosaminoglycan of high molecular weight with important biological and physicochemical functions. Although hydrogels derived from HA are effective biomaterials for soft tissue regeneration, they are generally brittle, or require complicated synthetic procedures. A simple one-pot synthesis method of mechanically strong HA hydrogels would be attractive for many application areas. Here, we present preparation of HA hydrogels via free-radical copolymerization of methacrylated HA (GMHA) and N,N-dimethylacrylamide (DMA) in aqueous solutions. GMHA was synthesized by methacrylation of native HA at various levels of methacrylation between 4 and 25% corresponding to 115-721 pendant methacrylate groups per GMHA molecule. It was found that GMHA acts as a multifunctional cross-linker during its copolymerization with DMA leading to the formation of interpenetrated and interconnected polymer networks. The effective functionality of GMHA increases with its degree of methacrylation as well as with the DMA concentration. The viscoelastic and mechanical properties of HA hydrogels could be tuned by varying the degree of methacrylation of GMHA and DMA concentration. A significant improvement in the mechanical performance of the hydrogels was observed when DMA is replaced with methacrylic acid monomer. By adjusting the synthesis parameters, hydrogels with a Young’s modulus of around 200kPa could be prepared that sustain up to 20MPa stresses at 96% compression.

Publisher URL: www.sciencedirect.com/science

DOI: S0014305717308893

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.