4 years ago

Salmon calcitonin-loaded PLGA microspheres/calcium phosphate cement composites for osteoblast proliferation

Salmon calcitonin-loaded PLGA microspheres/calcium phosphate cement composites for osteoblast proliferation
Bin Ma, Qiang Zhou, Cui Tang, Ruixue Wu
To improve the efficacy of salmon calcitonin (SCT) on disuse osteoporosis-induced bone fracture, the sustained-release vehicles delivered to bone fractures should be developed. In this study, SCT-loaded poly(d,l-lactic-co-glycolic acid) microspheres (SCT-PLGA MS) with 20 kDa-COOH and 40 kDa-COOH (SCT-PLGA-20 COOH MS and SCT-PLGA-40 COOH MS) are incorporated into calcium phosphate cement (CPC) at various mass ratios. The cumulative release and mechanical properties of SCT-PLGA MS/CPC composites decrease as PLGA MS/CPC mass ratio increase. Scanning electron microscopy images and the mass loss of composites indicate the MS from 20% SCT-PLGA MS/CPC composites have mostly degraded after 8 weeks. In addition, SCT released from the 20% SCT-PLGA-20 MS/CPC composites significantly facilitate proliferation and differentiation of MC3T3-E1 cells. In conclusion, 20% SCT-PLGA-20 COOH MS/CPC composites exhibit the sustained drug release, proper CPC degradation, good mechanical properties, and preferable osteoblast proliferation, which would be beneficial to their in vivo applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45486.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/app.45486

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