4 years ago

Prospects use of hybrid layered double hydroxides-polyacrylamide as controlled release media for antibiotic molecules

Prospects use of hybrid layered double hydroxides-polyacrylamide as controlled release media for antibiotic molecules
N'guadi Blaise Allou, Palakshi Bordoloi, Rajib Lochan Goswamee
Some controlled-release media containing two commercial antibiotic molecules, viz. Amoxicillin (AMX) and Ampicillin (AMP), were prepared using layered double hydroxides (LDH) intercalated and extended by polyacrylamide. The polycarylamide was prepared in situ by polymerization of acrylamide monomer intercalated in the interlayers of LDH. The LDH-polyacrylamide-antibiotic hybrid nanocomposites were characterized by various techniques like Fourier transform infrared (FT-IR), powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), and field emission scanning electron microscopy (FE-SEM). The results from these characterizations have shown the successful incorporation of the antibiotics in the interlayers and provided important information regarding their interlayer structure. The nanocomposites showed increased thermal stability in TGA. The loading of antibiotic in the PAM/Mg-Al nanocomposite was found to be 36.33% for AMX and 52.38% for AMP. The improved antibacterial activity of hybrid nanocomposite was evaluated against Escherichia coli using the wells diffusion technique. The aliquot samples in agar media drug release study were found to be highly effective against microorganisms. The sustained release of antibiotic drug from the hybrid nanocomposite was also verified. The release rate at pH 7.4 phosphate buffer was found slower than that at pH 4.6. It can be concluded that hybrid nanocomposites of LDH extended by in situ polymerized acrylamide are very suitable materials to host different antibiotics and their controlled release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45442.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/app.45442

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