3 years ago

Exhibiting caution with use of big data: The case of amphetamine in Iceland's prescription registry

Publication date: December 2018

Source: Research in Social and Administrative Pharmacy, Volume 14, Issue 12

Author(s): Ingunn Björnsdottir, Guri Birgitte Verne

Abstract
Background

Data from large electronic databases are increasingly used in epidemiological research, but golden standards for database validation remain elusive. The Prescription Registry (IPR) and the National Health Service (NHS) databases in Iceland have not undergone formal validation, and gross errors have repeatedly been found in Icelandic statistics on pharmaceuticals. In 2015, new amphetamine tablets entered the Icelandic market, but were withdrawn half a year later due to being substandard. Return of unused stocks provided knowledge of the exact number of tablets used and hence a case where quality of the data could be assessed.

Objective

A case study of the quality of statistics in a national database on pharmaceuticals.

Methods

Data on the sales of the substandard amphetamine were obtained from the Prescription Registry and the pharmaceuticals statistics database. Upon the revelation of discrepancies, explanations were sought from the respective institutions, the producer, and dose dispensing companies.

Results

The substandard amphetamine was available from 1.9.2015 until 15.3.2016. According to NHS, 73990 tablets were sold to consumers in that period, whereas IPR initially stated 82860 tablets to have been sold, correcting to 74796 upon being notified about errors. The producer stated 72811 tablets to have been sold, and agreed with the dose dispensing companies on sales to those. The producer’s numbers were confirmed by the Medicines Agency.

Conclusion

Over-registration in the IPR was 13.8% before correction, 2.7% after correction, and 1.6% in the NHS. This case provided a unique opportunity for external validation of sales data for pharmaceuticals in Iceland, revealing enormous quality problems. The case has implications regarding database integrity beyond Iceland.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.