3 years ago

Crosslinked clots formed independently of factor XIII and without fibrinogen‐to‐fibrin conversion – is this a liver‐specific phenomenon?

Ton Lisman


Both basic and applied studies dealing with aspects of hemostasis in liver diseases have spurred significant controversy over the last two decades[1]. Clinically, we have learnt that patients with liver diseases do not necessarily have a hemostatic defect resulting in a bleeding tendency. Instead, these patients appear in hemostatic balance due to a decline in both pro‐ and antihemostatic pathways, and may experience both bleeding and thrombotic complications when this reset hemostatic balance is offset[2].

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