Crosslinked clots formed independently of factor XIII and without fibrinogen‐to‐fibrin conversion – is this a liver‐specific phenomenon?
Both basic and applied studies dealing with aspects of hemostasis in liver diseases have spurred significant controversy over the last two decades. Clinically, we have learnt that patients with liver diseases do not necessarily have a hemostatic defect resulting in a bleeding tendency. Instead, these patients appear in hemostatic balance due to a decline in both pro‐ and antihemostatic pathways, and may experience both bleeding and thrombotic complications when this reset hemostatic balance is offset.
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Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.14328