3 years ago

Association between asthma and depression: A National Cohort Study

Hyo-geun Choi, Joo-hee Kim, Ji-young Park, Yong Il Hwang, Seung Hun Jang, Ki-suck Jung

Publication date: Available online 10 November 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Hyo-Geun Choi, Joo-Hee Kim, Ji-Young Park, Yong Il Hwang, Seung Hun Jang, Ki-Suck Jung


Patients with asthma often suffer from depression and vice versa. However, the temporal relationship between the two diseases has remained elusive.


The aim of this study was to determine the bidirectional relationship between asthma and depression in adults using national cohort samples in Korea.


Using the national cohort from the study by the Korean Health Insurance Review and Assessment Service, asthma patients and control participants were selected and matched by age group, sex, income group, region of residence, and prior medical histories. A stratified Cox proportional hazards model was used to analyze the hazard ratio (HR) of asthma with depression (Study I) and depression with asthma (Study II).


In Study I, the HR of depressive disorders was significantly higher in the patients with asthma than in the patients without asthma (HR = 1.35, 95% confidence interval [CI] = 1.31-1.40). In Study II, the HR of asthma in the patients with depression was significantly higher than that in the patients without depression (HR = 1.25, 95% CI = 1.21-1.29).


A bidirectional association between asthma and depression was observed in this study.

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