F1000Research
F1000Research
5 years ago

LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth [version 1; referees: 2 approved]

Meghan M Kozub, Martin E Fernandez-Zapico, Ryan M Carr, Gwen L Lomberk
Histone-modifying enzymes play a critical role in chromatin remodeling and are essential for influencing several genome processes such as gene expression and DNA repair, replication, and recombination. The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. LSD1 plays a pivotal role in a wide range of biological operations, including development, cellular differentiation, embryonic pluripotency, and disease (for example, cancer). This mini-review focuses on the role of LSD1 in chromatin regulatory complexes, its involvement in epigenetic changes throughout development, and its importance in physiological and pathological processes.

Publisher URL: https://f1000research.com/articles/6-2016/v1

DOI: 10.12688/f1000research.12169.1

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