3 years ago

Hypoglycaemia as a function of HbA1c in type 2 diabetes: Insulin glargine 300 U/mL in a patient‐level pooled analysis of EDITION 1, 2 and 3

Riccardo C. Bonadonna, Jean-François Yale, Claire Brulle-Wohlhueter, Emmanuelle Boëlle-Le Corfec, Pratik Choudhary, Timothy S. Bailey

Abstract

Basal insulin therapy often involves a compromise between achieving glycaemic targets and avoiding hypoglycaemia, dependent on how intensively insulin is titrated. In the phase 3a EDITION 1, 2 and 3 studies, insulin glargine 300 U/mL (Gla‐300) provided equivalent glycaemic control to insulin glargine 100 U/mL (Gla‐100) with less hypoglycaemia in people with type 2 diabetes mellitus (T2DM). The current study evaluated the rates of confirmed (≤3.9 mmol/L [≤70 mg/dL]) or severe hypoglycaemia over 6 months of treatment with Gla‐300 or Gla‐100 in these EDITION studies, as a function of HbA1c. Analysis was performed on patient‐level data pooled from the three EDITION studies, and annualized hypoglycaemia rate as a function of HbA1c at month 6 was fitted using a negative binomial regression model. People treated with Gla‐300 experienced a consistently lower rate of confirmed (≤3.9 mmol/L [≤70 mg/dL]) or severe hypoglycaemia versus those treated with Gla‐100, regardless of HbA1c at month 6. The results suggest that treatment with Gla‐300 versus Gla‐100 could allow people with T2DM to achieve equivalent glycaemic control with less hypoglycaemia.

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