ChemBioChem
ChemBioChem
5 years ago

A Nonbactericidal Zinc-Complexing Ligand as a Biofilm Inhibitor: Structure-Guided Contrasting Effects on Staphylococcus aureus Biofilm

A Nonbactericidal Zinc-Complexing Ligand as a Biofilm Inhibitor: Structure-Guided Contrasting Effects on Staphylococcus aureus Biofilm
Gopal Das, Sandipan Mukherjee, Durairaj Thiyagarajan, Aiyagari Ramesh, Vidushi Kapoor, Rajanikant Rai
The inside back cover picture shows the divergent anti-biofilm potentials of a thiosemicarbazone-based zinc-complexing ligand and a benzothiazole-based one. Mechanistic studies provided a fundamental understanding of how the structural differences in these non-bactericidal ligands had contrasting effects on the inhibition of biofilm growth (shown as a build up of blue spheres). This information could be used as a guide in designing compounds that would target the onset of staphylococcal biofilm formation. More information can be found in the full paper by G. Das, Aiyagari Ramesh, et al. (DOI: 10.1002/cbic.201700139).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cbic.201700372

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