3 years ago

Invasive Scopulariopsis alboflavescens infection in patient with acute myeloid leukemia

Keiji Kurata, Sho Nishimura, Hiroya Ichikawa, Rina Sakai, Yu Mizutani, Kei Takenaka, Seiji Kakiuchi, Yoshiharu Miyata, Akihito Kitao, Kimikazu Yakushijin, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Hiroshi Matsuoka, Issei Tokimatsu, Katsuhiko Kamei, Hironobu Minami

Abstract

Scopulariopsis alboflavescens is a soil saprophyte that is widely distributed in nature. Recently, there have been increasing number of reports of invasive infections with Scopulariopsis species in immunocompromised patients. In this report, we described an adult woman with acute myeloid leukemia and who developed S. alboflavescens pneumonia. Liposomal amphotericin B and voriconazole combination therapy was unsuccessful and the patient died because of pneumonia. Scopulariopsis is highly resistant to available antifungal agents and almost invariably fatal. This case report should alert clinicians to the importance of listing Scopulariopsis as a pathogenic fungus in immunocompromised patients.

Publisher URL: https://link.springer.com/article/10.1007/s12185-018-2496-1

DOI: 10.1007/s12185-018-2496-1

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