3 years ago

SIRT1 represses PKC‐zeta activity via regulating interplay of acetylation and phosphorylation in cardiac hypertrophy

Jingyan Li, Junying Huang, Jing Lu, Zhen Guo, Zhuoming Li, Hui Gao, Panxia Wang, Wenwei Luo, Sidong Cai, Yuehuai Hu, Kaiteng Guo, Luping Wang, Zhenzhen Li, Minghui Wang, Xiaolei Zhang, Peiqing Liu

Abstract

Background and Purpose

Activation of protein kinase C‐zeta (PKC‐zeta) is closely linked to the pathogenesis of cardiac hypertrophy. PKC‐zeta can be activated by certain lipid metabolites such as phosphatidylinositol (3,4,5)‐trisphosphate (PIP3) and ceramide. However, its endogenous negative regulators are not well defined. Here, the role of Sirtuin 1 (SIRT1)‐PKC‐zeta signaling axis and the underlying molecular mechanisms were investigated in cardiac hypertrophy.

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