3 years ago

Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes

Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes
Ilan Marek, Longyang Dian, Daniel S. Müller
The highly diastereo- and enantioselective formation of polysubstituted cyclopropanes was easily achieved through the asymmetric copper-catalyzed carbomagnesiation reaction of nonfunctionalized cyclopropene derivatives. The carbometalated species generated in situ readily undergo C−C and C−X bond-forming reactions with various electrophiles with complete retention of configuration. Magnesiated: Diastereo- and enantiomerically enriched cyclopropylmagnesium halides were synthesized through the copper-catalyzed addition of Grignard reagents across cyclopropenes. The carbometalated species generated in situ readily undergo C−C and C−X bond-forming reactions with various electrophiles with complete retention of configuration.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201701094

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