ChemBioChem
ChemBioChem
5 years ago

Inside Cover: Endo-α-Mannosidase-Catalyzed Transglycosylation (ChemBioChem 14/2017)

Inside Cover: Endo-α-Mannosidase-Catalyzed Transglycosylation (ChemBioChem 14/2017)
Kiichiro Totani, Akira Seko, Yuta Kasahara, Yoichi Takeda, Yukishige Ito, Ichiro Matsuo, Yayoi Yoshimura, Shogo Iwamoto
The inside cover picture shows a transglycosylation reaction catalyzed by Golgi endo-α-mannosidase (G-EM). We have demonstrated that G-EM hydrolysis activity can be employed to mediate transglycosylation by using α-fluorinated glucosyl mannoside as a donor. Systematic screening of various point mutants revealed that the E407D mutant had excellent transglycosylation activity. This optimized mutant is a versatile tool for synthesizing glucosylated high-mannose-type glycans. More information can be found in the communication by I. Matsuo et al. on page 1376 in Issue 14, 2017 (DOI: 10.1002/cbic.201700111).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cbic.201700334

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