ChemBioChem
ChemBioChem
5 years ago

Inside Back Cover: Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity (ChemBioChem 14/2017)

Inside Back Cover: Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity (ChemBioChem 14/2017)
Radka Chaloupkova, Jan Brezovsky, Petra Babkova, Eva Sebestova, Jiri Damborsky
The inside back cover picture shows the reconstruction of the ancestral sequence of haloalkane dehalogenases. Ancestral enzymes exhibited significantly enhanced thermodynamic stability compared to extant ones, as well as higher specific activities with a preference for short, multisubstituted halogenated substrates. Ancestral sequence reconstruction represents a powerful strategy for constructing highly stable and active catalysts that can further serve as robust templates for directed evolution. More information can be found in the full paper by R. Chaloupkova, J. Damborsky, et al. on page 1448 in Issue 14, 2017 (DOI: 10.1002/cbic.201700197).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cbic.201700335

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