3 years ago

Inside Back Cover: Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity (ChemBioChem 14/2017)

Inside Back Cover: Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity (ChemBioChem 14/2017)
Radka Chaloupkova, Jan Brezovsky, Petra Babkova, Eva Sebestova, Jiri Damborsky
The inside back cover picture shows the reconstruction of the ancestral sequence of haloalkane dehalogenases. Ancestral enzymes exhibited significantly enhanced thermodynamic stability compared to extant ones, as well as higher specific activities with a preference for short, multisubstituted halogenated substrates. Ancestral sequence reconstruction represents a powerful strategy for constructing highly stable and active catalysts that can further serve as robust templates for directed evolution. More information can be found in the full paper by R. Chaloupkova, J. Damborsky, et al. on page 1448 in Issue 14, 2017 (DOI: 10.1002/cbic.201700197).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cbic.201700335

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.