3 years ago

Smart wound dressing based on κ–carrageenan/locust bean gum/cranberry extract for monitoring bacterial infections

Karine Modolon Zepon, Maryane Modolon Martins, Morgana Souza Marques, Julia Maia Heckler, Fernando Dal Pont Morisso, Marina Griebeler Moreira, Ana Luiza Ziulkoski, Luiz Alberto Kanis

Publication date: Available online 12 November 2018

Source: Carbohydrate Polymers

Author(s): Karine Modolon Zepon, Maryane Modolon Martins, Morgana Souza Marques, Julia Maia Heckler, Fernando Dal Pont Morisso, Marina Griebeler Moreira, Ana Luiza Ziulkoski, Luiz Alberto Kanis

Abstract

A smart wound dressing based on carrageenan (κC), locust bean gum (LBG), and cranberry extract (CB) for monitoring bacterial wound infections was developed and characterized using UV-visible spectroscopy, FT-IR, and SEM. The mechanical, swelling, cytotoxic and pH sensor properties were also investigated. UV-visible spectra demonstrated that the obtained κC:LBG:CB hydrogel film exhibited a visible change of colors as it was immersed in PBS solution pH 5.0, 7.3 and 9.0. The spectra of FT-IR suggested that chemical interactions had occurred between κC and CB extract. The obtained κC:LBG:CB hydrogel film exhibited adequate mechanical properties and a swelling behavior dependent on pH. Cytotoxicity tests indicated that κC:LBG:CB hydrogel film had dose-dependent cytotoxicity against NIH 3T3 fibroblast cells. The in vitro studies using Staphylococcus aureus and Pseudomonas aeruginosa demonstrated that the color changes of the κC:LBG:CB hydrogel film could be observed by naked eyes, confirming the potential use of the obtained hydrogel film as a visual system for monitoring bacterial wound infections.

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