3 years ago

Ectopic nerve growth factor prevents proliferation in glioma cells by senescence induction

Daniela Meco, Angela Maria Di Francesco, Linda Melotti, Antonio Ruggiero, Riccardo Riccardi

Abstract

Objective

The neurotrophin nerve growth factor (NGF) affects survival, regulation and differentiation of both central and peripheral nervous system neurons. NGF exerts its effects primarily through tropomyosin receptor kinase A (TrkA), inducing a cascade of tyrosine kinase‐initiated responses. In spite of its importance, the general behavior of NGF looks contradictory: its effects can be both stimulatory and inhibitory. The present study aims to explore the molecular mechanisms induced by NGF in glioma cancer cells.

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