3 years ago

Plasmonic-Based Electrochemical Impedance Imaging of Electrical Activities in Single Cells

Plasmonic-Based Electrochemical Impedance Imaging of Electrical Activities in Single Cells
Shaopeng Wang, Wei Wang, Yunze Yang, Ming Gao, Nongjian Tao, Jie Wu, Xian-Wei Liu
Studying electrical activities in cells, such as action potential and its propagation in neurons, requires a sensitive and non-invasive analytical tool that can image local electrical signals with high spatial and temporal resolutions. Here we report a plasmonic-based electrochemical impedance imaging technique to study transient electrical activities in single cells. The technique is based on the conversion of the electrical signal into a plasmonic signal, which is imaged optically without labels. We demonstrate imaging of the fast initiation and propagation of action potential within single neurons, and validate the imaging technique with the traditional patch clamp technique. We anticipate that the plasmonic imaging technique will contribute to the study of electrical activities in various cellular processes. Plasmonic imaging: A plasmonic-based electrochemical impedance imaging approach for electrical activity visualization in single cells is reported. The technique has a temporal resolution of 10 μs, which can be used for mapping the propagation of an electrical signal in a cell.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201703033

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