3 years ago

Frequency of CD8 + regulatory T cells in the multiple sclerosis patients: a systematic review and meta-analysis

Ali Seidkhani-Nahal, Ali Noori-Zadeh, Salar Bakhtiyari, Afra Khosravi

Abstract

Multiple sclerosis (MS) is a neuro-immunological demyelinating disease. From the immunological aspects, it is well accepted that T cells play a pivotal role in the etiology of the disease. T helper (Th) 1 and Th17 cells are thought to be the main pathogenic T cells in the pathogenesis of MS and are known as effector T cells. As the self-reactive T lymphocytes can escape clonal deletion in the thymus and subsequently are released into the periphery, there is an urgent need for peripheral tolerance, which is executed by the specialized regulatory T (Treg) cells. Interestingly, CD8+ regulatory T (Treg) cells have also been identified among lymphocyte subtypes. The peripheral CD8+ Treg cells frequency in MS subjects in comparison with healthy controls is the objective of the current study using the systematic review and meta-analysis. A systematic literature search was carried out using specialized biomedical databases of Pubmed, Pubmed Central, Medline, Google Scholar, Embase and SCOPUS databases without the beginning date restriction until January 2018 in English language. The results were as follows: OR 15.548 (95% confidence interval 1.954–123.742) using the random-effects model. The P value for test of significance of the total OR was examined by the z test and calculated as 0.010 (clearly considered as statistically significant). Based on our findings, the number of CD8+ Treg cells in the blood of MS subjects is significantly different as compared to healthy controls.

Publisher URL: https://link.springer.com/article/10.1007/s13760-018-1028-3

DOI: 10.1007/s13760-018-1028-3

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.