Blood‐brain barrier permeability measured using dynamic contrast‐enhanced magnetic resonance imaging: a validation study
- The blood‐brain barrier (BBB) is an important and dynamic structure which contributes to homeostasis in the central nervous system.
- BBB permeability changes occur in health and disease but measurement of BBB permeability in humans is not straightforward.
- Dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) can be used to model the movement of gadolinium contrast into the brain, expressed as the influx constant Ki.
- This paper provides evidence that Ki as measured by DCE‐MRI behaves as expected for a marker of overall BBB leakage.
- These results support the use of DCE‐MRI for in vivo studies of human BBB permeability in health and disease.
Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1113/JP276887