3 years ago

Blood‐brain barrier permeability measured using dynamic contrast‐enhanced magnetic resonance imaging: a validation study

Aravinthan Varatharaj, Maria Liljeroth, Angela Darekar, Henrik B.W. Larsson, Ian Galea, Stig P. Cramer

Abstract

Key points

  • The blood‐brain barrier (BBB) is an important and dynamic structure which contributes to homeostasis in the central nervous system.
  • BBB permeability changes occur in health and disease but measurement of BBB permeability in humans is not straightforward.
  • Dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) can be used to model the movement of gadolinium contrast into the brain, expressed as the influx constant Ki.
  • This paper provides evidence that Ki as measured by DCE‐MRI behaves as expected for a marker of overall BBB leakage.
  • These results support the use of DCE‐MRI for in vivo studies of human BBB permeability in health and disease.

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