3 years ago

Blood‐brain barrier permeability measured using dynamic contrast‐enhanced magnetic resonance imaging: a validation study

Aravinthan Varatharaj, Maria Liljeroth, Angela Darekar, Henrik B.W. Larsson, Ian Galea, Stig P. Cramer


Key points

  • The blood‐brain barrier (BBB) is an important and dynamic structure which contributes to homeostasis in the central nervous system.
  • BBB permeability changes occur in health and disease but measurement of BBB permeability in humans is not straightforward.
  • Dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) can be used to model the movement of gadolinium contrast into the brain, expressed as the influx constant Ki.
  • This paper provides evidence that Ki as measured by DCE‐MRI behaves as expected for a marker of overall BBB leakage.
  • These results support the use of DCE‐MRI for in vivo studies of human BBB permeability in health and disease.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.