Ginkgo leaf-based synthesization of nitrogen-doped carbon quantum dots for highly sensitive detection of salazosulfapyridine in mouse plasma
Publication date: Available online 13 November 2018
Source: Journal of Pharmaceutical and Biomedical Analysis
Author(s): Xiaohua Jiang, Dongmiao Qin, Guichun Mo, Jinsu Feng, Chunhe Yu, Weiming Mo, Biyang Deng
A simple, economical hydrothermal strategy for synthesizing nitrogen-doped carbon quantum dots (N-CQDs) was developed using Ginko leaves as a carbon source. These N-CQDs have strong blue fluorescence, excitation-relevant emissions, high monodispersity, good stability, good water solubility, and a 22.8% fluorescence quantum yield. They average 3 nm in size, and have a maximum excitation and emission wavelengths of 350 and 436 nm, respectively. They are used as an effective fluorescent sensing platform for the label-free sensitive detection of salazosulfapyridine (SASP) due to the strong quenching effect of SASP. When SASP concentration is 0.1-80 μmol/L, there is a good linear relationship with a detection limit of 40 nmol/L. This method was successfully applied to detect SASP in mouse plasma. The results show that the SASP recovery range was 96%-101%. RSDs ranged from 2.6% to 3.1%.