3 years ago

The effects of solution additives and gas‐phase modifiers on the molecular environment and conformational space of common heme proteins

David Butcher, Jaroslava Miksovska, Mark E. Ridgeway, Melvin A. Park, Francisco Fernandez-Lima

Abstract

RATIONALE

The molecular environment is known to impact the secondary and tertiary structure of biomolecules both in solution and in the gas‐phase, shifting the equilibrium between different conformational and oligomerization states. However, there is a lack of studies monitoring the impacts of solution additives and gas‐phase modifiers on biomolecules characterized using ion mobility techniques.

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