3 years ago

A dansyl-appended N-heterocycle for Cu2+ and S2− recognition via a displacement mode

Xu Wang, Peng Xia, Xiaohuan Huang

Publication date: Available online 13 November 2018

Source: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Author(s): Xu Wang, Peng Xia, Xiaohuan Huang


A novel l-proline based heterocycle 3 of C2 symmetry has been designed and synthesized for cation and anion recognition in aqueous solution. Ligand 3 shows a strong affinity to Cu2+ ion, and their interaction induces a remarkable fluorescence quenching in DMSO:H2O = 9:1 (HEPES buffer, 0.01 M, pH 7.4) among various metal ions. Both the in-situ generated and isolated 3-Cu2+ complex exhibit specific fluorescence recovery upon addition of S2−, even in the presence of S2O32−, L-histidine, and thiol-containing amino acids. For this dual functional switch, a combination of 1H NMR titration, ESI mass and FT-IR spectra suggest that its sensing behavior is via a displacement mode. Sequential “on-off-on” fluorescence bio-imaging of the heterocycle 3 to Cu2+ and S2− was carried out in HeLa cells.

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