3 years ago

[ASAP] Polycyclic Arene Synthesis by Annulative p-Extension

[ASAP] Polycyclic Arene Synthesis by Annulative p-Extension
Hideto Ito, Yasutomo Segawa, Kei Murakami, Kenichiro Itami
Annulative π-extension (APEX) has emerged as a powerful and efficient synthetic method for the construction of polycyclic aromatic hydrocarbons, nanographenes, and π-extended fused heteroarenes. In contrast to classical multistep syntheses requiring substrate prefunctionalization, APEX reactions minimize the number of preparative steps by direct C–H activation of small aromatic templates. In this Perspective, we review recently reported APEX reactions to shed light on the utility, scope, and promise of this approach for next-generation syntheses of polycyclic arenes.

Publisher URL: http://dx.doi.org/10.1021/jacs.8b09232

DOI: 10.1021/jacs.8b09232

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