Macromolecular Bioscience
Macromolecular Bioscience
5 years ago

3D Printed Anchoring Sutures for Permanent Shaping of Tissues

3D Printed Anchoring Sutures for Permanent Shaping of Tissues
Shahrouz Taranejoo, Yanhui Liu, Reza Nassab, Wei Wei, Ali Khademhosseini, Huazhe Yang, Ali Akpek, Fatemeh Shahriyari, Yuxiao Li, Yu Shrike Zhang, Ali Tamayol, Hae Lin Jang, Xiaofei Guan
Sutures are one of the most widely used devices for adhering separated tissues after injury or surgery. However, most sutures require knotting, which can create a risk of inflammation, and can act as mechanically weak points that often result in breakage and slipping. Here, an anchoring suture is presented with a design that facilitates its propagation parallel to the suturing direction, while maximizing its resistive force against the opposite direction of external force to lock its position in tissues. Different microstructures of suture anchors are systematically designed using orthogonal arrays, and selected based on shape factors associated with mechanical strength. 3D printing is used to fabricate different types of hollow microstructured suture anchors, and optimize their structure for the effective shaping of tissues. To define the structural design for fixing tissues, the maximum force required to pull 3D printed anchors in different directions is examined with tissues. The tissue reshaping function of suture anchors is further simulated ex vivo by using swine ear, nose, and skin, and bovine muscle tendon. This study provides advantages for building functional sutures that can be used for permanently reshaping tissues with enhanced mechanical strength, eliminating the need for knotting to improve surgical efficiency. Suture anchors that can permanently reshape tissues are designed using orthogonal arrays and 3D printed in a way that can smoothly propagate along the suturing direction, while have maximized resistive force against external force once it is fixed in tissues. Tissue reshaping function of anchoring sutures is demonstrated by using swine skin, ear, and nose, and bovine tendon.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mabi.201700304

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